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Product Pipeline

Focused on Innovation

CSL is a global leader in developing and delivering high quality medicines that treat people with rare and serious diseases. Working every day as if people’s lives depend on it, CSL’s R&D fuels the company’s sustainable growth by advancing world-class science, technology and collaboration. Our strong R&D pipeline utilises its expertise in plasma protein technology, recombinant protein technology, cell and gene therapy and vaccines technology to develop and deliver innovative medicines that address unmet medical needs or enhance current treatments in five Therapeutic Areas - Immunoglobulins, Hematology, Cardiovascular & Renal, Transplant & Immunology and Vaccines. Our R&D portfolio focuses on innovation in new products, improved products and manufacturing expertise ensuring our continued growth.

Core Capabilities

as demonstrated in our product pipeline 

Phase I

Phase II

Phase III

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CSL R&D Portfolio – FY25
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HIZENTRA® (SCIg) 20% Liquid

Subcutaneous 20% Immune Globulin (SCIg)(Plasma) to treat Primary Immunodeficiency (PID), Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), Secondary Immunodeficiency (SID)

PRIVIGEN® (IVIg) 10% Liquid

Intravenous 10% Immune Globulin (IVIg)(Plasma) for the treatment of Primary Immunodeficiency (PID), Chronic Inflammatory Demyelinating Polyneuropathy (CIDP), Secondary Immunodeficiency (SID), Chronic Immune Thrombocytopenia (ITP)

ZEMAIRA®/RESPREEZA® Alpha 1 Antitrypsin (AAT Deficiency)

Human Alpha 1 Antitrypsin (AAT) (Plasma) for chronic augmentation and maintenance therapy in adults with A1-PI deficiency and emphysema

AFSTYLA® rFVIII (Hem A)

Recombinant factor VIII product for the treatment of adults and children with hemophilia A.

IDELVION® rFIX-FP (Hem B)

Long-acting recombinant factor IX product for the treatment of hemophilia B.

HEMGENIX® (Hem B)

Adeno-associated virus vector-based gene therapy indicated for treatment of adults with Hemophilia B (congenital Factor IX deficiency).

ANDEMBRY® Anti-FXIIa mAb (HAE)

Subcutaneous humanised anti-factor XIIa monoclonal antibody for the treatment of Hereditary Angioedema (HAE).

FILSPARI®(Sparsentan) Dual ETA & AT1 antagonist (IgAN)*

Oral, non-immunosuppressive, single-molecule, dual endothelin angiotensin receptor antagonist (DEARA) with high selectivity for the ETAR and AT1R for treatment of immunoglobulin A nephropathy (IgAN).

KORSUVA®/KAPRUVIA® KOR. agonist (CKD-aP)*

Difelikefalin - a kappa-opioid receptor (KOR) agonist for treatment of moderate-to-severe pruritus associated with CKD in adult patients on hemodialysis.

RAYALDEE® Oral ext. release calcifediol (SHPT)*

Orally administered, prolonged-release formulation of calcifediol for the treatment of secondary hyperparathyroidism (SHPT) in adults with stage 3 or 4 chronic kidney disease (CKD) and vitamin D insufficiency or deficiency.

TAVNEOS® Oral C5a receptor inhibitor (AAV)*

Orally administered, highly potent and selective inhibitor of C5aR1 (complement C5a receptor 1) for the treatment of anti-neutrophil cytoplasmic auto-antibody-associated vasculitis (ANCA)-associated vasculitis (AAV).

VELPHORO® Sucroferric oxyhydroxide (Serum P control in CKD)

A non-calcium, iron-based phosphate binder used for the control of serum phosphorus levels in patients with chronic kidney disease (CKD) on hemodialysis or peritoneal dialysis.

VELTASSA® Oral potassium binder (HK)

A non-absorbed, oral potassium binder for the treatment of hyperkalemia.

AUDENZ®/CELLDEMIC® Adjuvanted Cell-based Monovalent Influenza A (H5N1) Vaccine

For protection against Pandemic Influenza A (H5N1)

FLUAD® Adjuvanted Egg-based Influenza Vaccine

Egg-based vaccine combined with CSL Seqirus' proprietary adjuvant, MF59® (an additive that acts to strengthen the immune response to vaccination) for protection against influenza A (H5N1) - the 'bird-flu' strain.

FLUCELVAX® Cell-based Influenza Vaccine

For protection against seasonal influenza viruses in adults and children 6 months of age and older.

FOCLIVIA®/AFLUNOV® Adjuvanted Egg-based Influenza A (H5N1) Vaccine

Pre-pandemic, egg-based vaccine combined with CSL Seqirus' proprietary adjuvant, MF59® (an additive that acts to strengthen the immune response to vaccination), for protection against influenza A (H5N1) - the 'bird-flu' strain.

KOSTAIVE® sa-mRNA Vaccine (COVID)*

Novel seasonal COVID-19 booster vaccine using self-amplifying platform offering higher efficacy and longer duration and breadth of protection at lower doses of mRNA.

CSL403 (aTIVc) Adjuvanted Cell-based Trivalent Influenza Vaccine

Trivalent Seasonal Influenza Vaccine (Adjuvanted; Cell-based). High dose vaccine offering protection against different influenza virus strains.

*Indicates partnered projects

#Further development in event of pandemic

This pipeline is current as at 30th June 2025